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Initially, all rats received intravenous (i.v.) infusions of KCN (30 μg/100 μL) followed by AVP (10 ng/100 μL) (Protocol 1). Subsequently, animals received either i.v. infusion of V1aR ANT (5 μg/100 μL) followed by AVP (10 ng/100 μL) (Protocol 2) or after carotid body denervation received i.v. infusions of KCN (30 μg/100 μL) and AVP (10 ng/100 μL) (Protocol 3).

Journal: Journal of Clinical Medicine

Article Title: Vasopressin Contributes to Respiratory and Cardiovascular Regulation in Spontaneously Hypertensive and Normotensive Rats

doi: 10.3390/jcm14228019

Figure Lengend Snippet: Initially, all rats received intravenous (i.v.) infusions of KCN (30 μg/100 μL) followed by AVP (10 ng/100 μL) (Protocol 1). Subsequently, animals received either i.v. infusion of V1aR ANT (5 μg/100 μL) followed by AVP (10 ng/100 μL) (Protocol 2) or after carotid body denervation received i.v. infusions of KCN (30 μg/100 μL) and AVP (10 ng/100 μL) (Protocol 3).

Article Snippet: Selective V1aR antagonist (d(CH2)51,Tyr(Me)2,Arg8) Vasopressin (Tocris, Bristol, UK) was administered i.v. (5 μg/100 μL).

Techniques:

Cardiorespiratory responses to AVP, AVP after carotid body denervation (CBX), V1aR ANT, and AVP after the V1aR ANT. ( A ) change in mean arterial blood pressure (ΔMABP; mm Hg); ( B ) heart rate (ΔHR); ( C ) percentage change in femoral artery blood flow (ΔFABF); ( D ) change in minute ventilation (ΔMV); ( E ) change in respiratory rate (ΔRR); ( F ) change in the end-tidal CO 2 (ΔETCO2). Boxplots: box—IQR; whiskers—max-min; plus—mean; dash—median. Red squares—SHR rats; blue squares—WKY rats. Dots represent individual data points. * p < 0.05, ** p < 0.01, **** p < 0.0001—after vs. before intervention; # p < 0.05, ## p < 0.01, #### p < 0.0001—SHR vs. WKY.

Journal: Journal of Clinical Medicine

Article Title: Vasopressin Contributes to Respiratory and Cardiovascular Regulation in Spontaneously Hypertensive and Normotensive Rats

doi: 10.3390/jcm14228019

Figure Lengend Snippet: Cardiorespiratory responses to AVP, AVP after carotid body denervation (CBX), V1aR ANT, and AVP after the V1aR ANT. ( A ) change in mean arterial blood pressure (ΔMABP; mm Hg); ( B ) heart rate (ΔHR); ( C ) percentage change in femoral artery blood flow (ΔFABF); ( D ) change in minute ventilation (ΔMV); ( E ) change in respiratory rate (ΔRR); ( F ) change in the end-tidal CO 2 (ΔETCO2). Boxplots: box—IQR; whiskers—max-min; plus—mean; dash—median. Red squares—SHR rats; blue squares—WKY rats. Dots represent individual data points. * p < 0.05, ** p < 0.01, **** p < 0.0001—after vs. before intervention; # p < 0.05, ## p < 0.01, #### p < 0.0001—SHR vs. WKY.

Article Snippet: Selective V1aR antagonist (d(CH2)51,Tyr(Me)2,Arg8) Vasopressin (Tocris, Bristol, UK) was administered i.v. (5 μg/100 μL).

Techniques: